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KMID : 0378019700130060080
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New Medical Journal
1970 Volume.13 No. 6 p.80 ~ p.84
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Autoradiographic Studies on the DNA Synthesis of Oral Mucous Membrane using ^(3)H-thymidine in the Prathyroidectomized Chicken
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Abstract
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The author had studied on the synthesis of DNA of oral mucous membrane of parathyroidectomized chicken by means of autoradiography using 3H-thymidine.
The administration of tritiated thymidine was preceded to parathyroidectomy for two hours, intraperitoneally, a dose of 0. 9 microcurie /gram body weight, and sacrificed thereafter 10 hours.
The experimental animals weighing about 400 grams were divided into 5 groups; 6 hours, 10 hours, 18 hours and 32 hours after parathyroidectomy performed and the control group. The results were as follows;
1. The synthesis of DNA in oral mucous membrane was decreased in the parathyroidectomized group.
2. The acute decrement of DNA synthesis of oral mucous membrane was revealed after parathyroidectomy performed, and it recovered gradually.
3. The cell renewal rate of oral mucous membrane was lowest at 18 hours after parathyroidectomy performed.
4. Silver grains were appeared densely at the basal cell layer.
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